Maintaining healthy blood sugar (glucose) levels can often pose a challenge. The foods consumed today most often highly processed and refined, have excessive sugar and carbohydrate levels, and offer very little in the way of nutrients and fiber. Additionally, genetic predisposition, high stress levels and an inadequate exercise regimen can make it even more difficult to maintain adequate blood sugar levels. Healthy blood sugar regulation requires that a number of metabolic factors work at optimal capacity. This delicate balance of blood sugar levels is crucial for regulating the body’s production of storage energy and fuel. Micronutrients such as chromium, biotin and vanadyl sulfate are required to support enzymatic reactions and cellular signaling systems that maintain the body’s homeostasis.
Diaxinol is a natural and synergistic formula for maintaining balanced blood sugar. By helping to enhance signaling at the cellular level, Diaxinol’s blend of natural extracts and vitamins support healthy blood glucose levels. Diaxinol’s unique and effective formulation contains five ingredients provided at targeted doses for maximum efficacy. Lipoic acid is a potent antioxidant that supports insulin regulation, glucose utilization and microcirculation throughout the body. Cinnulin®, a patented 20:1 aqueous cinnamon extract supports both balanced glucose metabolism and healthy blood lipid levels. Chromium is added to support glucose tolerance factor production, a critical component in cellular uptake of glucose, and Gymnema sylvestre (gymnema leaf extract) helps modulate glucose absorption in the intestines. Biotin and vanadyl sulfate are also included to support optimal insulin sensitization.
2 capsules per day or as recommended by your health care professional.
Alpha Lipoic Acid
Alpha lipoic acid (ALA) is a nutrient that is required for the cellular breakdown of carbohydrates and fatty acids. ALA scavenges free radicals in the body while aiding in the regeneration of the body’s antioxidants including vitamin C, vitamin E and glutathione. Through its antioxidant boosting mechanisms, ALA helps maintain healthy blood vessel and circulatory health. Among its multifaceted roles, ALA has also been shown to support healthy blood sugar balance by activating a protein called adenosine mono-phosphate kinase (AMPK), a major regulator of cellular energy. AMPK coordinates both long-term and short-term metabolic changes, leading to an improvement in energy production and a reduction of energy storage. AMPK activates cellular metabolism by improving insulin sensitivity, down-regulating genes involved in fat storage and activating genes involved with burning fat. A study using a dose of 600 mg/day of ALA over three months demonstrated that ALA helps support healthy lipid levels while improving oxidative stress (reducing free radical damage) by 38%. An additional study examining the effects of ALA on 74 subjects found that within the four week placebo-controlled trial, administration of 600 mg of ALA per day significantly enhanced glucose transport and utilization.
Cinnulin® (Cinnamon Bark Extract)
Studies have demonstrated that cinnamon has a beneficial effect on maintaining healthy blood sugar levels, first by inhibiting the enzymes that cause insulin resistance, and second by increasing the insulin sensitivity. Diaxinol includes Cinnulin® which is made using a patented process that extracts the water soluble components of cinnamon into a potent 20:1 extract (500 mg of Cinnulin® is equivalent to approximately 10g of whole cinnamon powder). Cinnulin® is standardized to contain doubly-linked polyphenol type A polymers, the bioactive component which has been shown to be effective in clinical trials. In a study examining the effects of Cinnulin®, 24 men and women were given 250 mg of Cinnulin®, or placebo, twice per day. Cinnulin® helped to maintain healthy blood sugar levels in 83% of subjects in the treatment group, compared to 33% in the placebo group. Cinnulin® has also been shown to support healthy body composition by increasing lean body bass while reducing body fat. An additional study examined the effects of 6 g of cinnamon on glucose levels in subjects consuming 50 g of carbohydrates (instant farina cereal). The researchers found that the addition of cinnamon to cereal helped to improve glucose response measurements during the 15, 30, 45, and 60 minutes following the carbohydrate challenge.
Chromium is a critical element in the molecule called glucose tolerance factor (GTF), a complex shown to be crucial for the uptake of glucose into the cells. Studies using 1000 mcg/day of chromium have demonstrated that chromium helps maintain healthy blood sugar balance, insulin sensitivity and blood lipids. In a study examining the effects of nutrients on blood sugar and lipid regulation, 43 patients were given 600 mcg of chromium along with 2 mg of biotin per day, or placebo. After four weeks, the combination of chromium and biotin was found to have a significant effect on supporting healthy blood sugar balance, while helping to maintain healthy triglyceride and high-density lipoprotein (HDL) cholesterol levels in the treatment group.
Biotin is a B vitamin that plays a major role in the oxidation of fats and carbohydrates (multi-step process that breaks down fatty acids and carbohydrates to produce energy). Biotin plays numerous roles in maintaining healthy blood sugar balance which includes stimulating glucose-induced insulin secretion, enhancing insulin sensitivity and accelerating glucose metabolism in the liver and pancreas. Biotin also activates glucokinase, an enzyme involved in glucose utilization. Additional research has found that biotin supplementation increases the number of insulin secreting beta cells in the pancreas.
Gymnema Leaf Extract
An Aryurvedic botanical used for thousands of years, gymnema has a long history of use for its blood sugar balancing properties. Gymnema contains compounds called gymnemic acids which help reduce the absorption of glucose in the intestines and delays the rapid release of glucose into the bloodstream. In one study, 400 mg daily of GS4 (an extract of gymnema leaves) consumed for 18-20 months helped maintain blood sugar metabolism. Gymnema has been found to block the taste of sweetness and has a stimulating effect on insulin-secreting pancreatic beta cells. In a study in which 400 mg of gymnema extract was given to 22 individuals over a period of 20 months, gymnema leaf extract was shown to help maintain healthy blood glucose levels.
Vanadyl sulfate (VS) is the stable, inorganic form of vanadium, a mineral shown to mimic the action of insulin and plays a major role in promoting healthy glucose metabolism. In a three week study, VS given at 100 mg/day significantly improved insulin sensitivity. VS was also shown to decrease glucose production by about 20%. An additional study using 100 mg/ day of VS for three weeks also demonstrated an improvement in insulin sensitivity while helping to maintain healthy glucose levels.