Antioxidant activity is needed to protect against cell damage caused by free radicals. The oxidative stress and free radicals generated during Phase I of biotransformation need to be removed to protect the liver from toxin-induced free radical damage and support liver cell protection and regeneration. Glutathione production (from N-acetyl cysteine) increases antioxidant protection and supports liver detoxification through enhancement of the glucuronidation pathways and Phase II processes. Silymarin and other phytonutrients protect against glutathione depletion and increase hepatocyte protein synthesis resulting in enhanced detoxification function.
Vegetable blends high in ORAC value (oxygen radical absorbance capacity) include health promoting compounds, like sulforaphane and glucosinolates. Sulforaphane induces Phase II detoxification enzymes and supports the body’s response to oxidative stress to help balance inflammation. Glucosinolates serve as precursors for biologically active metabolites, which induce Phase II enzymes via the activation of Nrf2, the master cellular switch responsible for antioxidant production.